%0 Journal Article
%T Parallel solid-phase synthesis of diaryltriazoles
%A Matthias Wrobel
%A Jeffrey Aub¨¦
%A Burkhard K£¿nig
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.115
%X A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein¨Cprotein interactions.
%K chemical diversity
%K Huisgen cycloaddition
%K library synthesis
%K peptidomimetics
%K solid phase synthesis
%K triazole
%U http://dx.doi.org/10.3762/bjoc.8.115