%0 Journal Article
%T Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes
%A Jing Sun
%A Hong Gao
%A Qun Wu
%A Chao-Guo Yan
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.211
%X In the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in situ generated ¦Â-enamino ester with the in situ formed aromatic imine.
%K ¦Â-enamino ester
%K domino reaction
%K electron-deficient alkyne
%K Povarov reaction
%K tetrahydroquinoline
%U http://dx.doi.org/10.3762/bjoc.8.211