%0 Journal Article
%T Automated synthesis of sialylated oligosaccharides
%A Davide Esposito
%A Mattan Hurevich
%A Bastien Castagner
%A Cheng-Chung Wang
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.183
%X Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl ¦Á-(2¡ú3) and ¦Á-(2¡ú6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
%K automated synthesis
%K disaccharide building blocks
%K solid-phase synthesis
%K sialic acid
%K sialosides
%U http://dx.doi.org/10.3762/bjoc.8.183