%0 Journal Article
%T An intramolecular inverse electron demand Diels¨CAlder approach to annulated ¦Á-carbolines
%A Zhiyuan Ma
%A Feng Ni
%A Grace H. C. Woo
%A Sie-Mun Lo
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.93
%X Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused ¦Á-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight ¦Á-carbolines was prepared by using this robust methodology for biological evaluation.
%K ¦Á-carboline
%K chemical diversity
%K inverse electron demand Diels¨CAlder
%K isatin
%K pyrido[2
%K 3-b]indole
%K 1
%K 2
%K 4-triazine
%U http://dx.doi.org/10.3762/bjoc.8.93