%0 Journal Article
%T C2-Alkylation of N-pyrimidylindole with vinylsilane via cobalt-catalyzed C¨CH bond activation
%A Zhenhua Ding
%A Naohiko Yoshikai
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.174
%X Direct C2-alkylation of an indole bearing a readily removable N-pyrimidyl group with a vinylsilane was achieved by using a cobalt catalyst generated in situ from CoBr2, bathocuproine, and cyclohexylmagnesium bromide. The reaction allows coupling between a series of N-pyrimidylindoles and vinylsilanes at a mild reaction temperature of 60 ¡ãC, affording the corresponding alkylated indoles in moderate to good yields.
%K alkylation
%K C¨CH functionalization
%K cobalt
%K indole
%K vinylsilane
%U http://dx.doi.org/10.3762/bjoc.8.174