%0 Journal Article
%T Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
%A John B. Bremner
%A Paul A. Keller
%A Stephen G. Pyne
%A Mark J. Robertson
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.142
%X The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl-substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2¨C4 ¦Ìg/mL) against antibiotic-resistant strains of Staphylococcus aureus and Enterococci (VRE, VSE), and against Staphylococcus epidermidis.
%K antibacterials
%K binaphthyls
%K cationic peptides
%K peptides
%K resistance
%K VISA
%K VRE
%U http://dx.doi.org/10.3762/bjoc.8.142