%0 Journal Article
%T N-Heterocyclic carbene/Br nsted acid cooperative catalysis as a powerful tool in organic synthesis
%A Rob De Vreese
%A Matthias D¡¯hooghe
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.43
%X The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Br nsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Br nsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.
%K Br nsted acids
%K cooperative catalysis
%K ¦Ã-lactams
%K N-heterocyclic carbenes
%K stereoselectivity
%U http://dx.doi.org/10.3762/bjoc.8.43