%0 Journal Article
%T Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system
%A Caterina Fraschetti
%A Matthias C. Letzel
%A Antonello Filippi
%A Maurizio Speranza
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.62
%X This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion¨Cmolecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects.
%K diastereomeric complexes
%K gas phase enantioselectivity
%K kinetics
%K mass spectrometry
%K resorcin[4]arene receptor
%U http://dx.doi.org/10.3762/bjoc.8.62