%0 Journal Article
%T Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis
%A Marcus Frings
%A Isabelle Thom¨¦
%A Carsten Bolm
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.164
%X For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.
%K anhydride opening
%K catalytic asymmetric Biginelli reaction
%K organocatalysis
%K sulfoximines
%K thioureas
%U http://dx.doi.org/10.3762/bjoc.8.164