%0 Journal Article
%T Engineering of indole-based tethered biheterocyclic alkaloid meridianin into ¦Â-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic ¦Ð-cyclization
%A Piyush K. Agarwal
%A Meena D. Dathi
%A Mohammad Saifuddin
%A Bijoy Kundu
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.220
%X A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-¦Â-carboline by cationic ¦Ð- cyclization. The strategy involves the introduction of an amino group at the C-5 of the pyrimidine ring and utilizing the nucleophilictiy of the C-2 in the indole ring to facilitate cationic ¦Ð-cyclization.
%K cyclization
%K indole
%K meridianin
%K natural products
%K nitrogen heterocycles
%U http://dx.doi.org/10.3762/bjoc.8.220