%0 Journal Article
%T Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations
%A Tobias Knobloch
%A Gerald Dr£żger
%A Wera Collisi
%A Florenz Sasse
%J Beilstein Journal of Organic Chemistry
%D 2012
%I 
%R 10.3762/bjoc.8.96
%X We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity.
%K ansamitocins
%K antibiotics
%K antitumor agents
%K mutasynthesis
%K natural products
%U http://dx.doi.org/10.3762/bjoc.8.96