%0 Journal Article
%T SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 5-METHYLPYRAZINE-2- CARBOHYDRAZIDE DERIVATIVES
%A MINIYAR P. B.1* AND MAKHIJA S. J.2
%J International Journal of Drug Development & Research
%D 2009
%I Chauhan Publishers
%X Here an attempt has been made to synthesize fourteen 5-methylpyrazine-2-carbohydrazide derivatives. Thesynthesized derivatives were assessed for their in-vitro anti-bacterial activity and minimum inhibitory concentration (MIC)against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and Gram-negative strains (Salmonella typhiand Escherichia coli). During the present work, 5-methylpyrazinoic acid was esterified with ethanol to get ethylpyrazinoateand it refluxed with hydrazine hydrate to yield the 5-methylpyrazinoic acid hydrazide. The obtained acidhydrazide was then condensed with various substituted aromatic aldehydes to yield various 5-methylpyrazine-2-carbohydrazide derivatives. The structures of newly synthesized compounds so obtained were confirmed by using IR,1HNMR, MS spectral data. All compounds gave satisfactory elemental analyses. The compounds PM 8-10, (i.e. 2,3 and 4-nitro benzaldehyde derivatives respectively) showed promising activity amongst the compounds tested against both theGram-positive and Gram-negative strains tested. .KEY WORDS:
%K 5-methylpyrazine
%K carbohydrazide
%K anti-bacterial
%K synthesis
%U http://www.ijddr.com/PDF/3.pdf