%0 Journal Article
%T ENHANCEMENT OF ORAL BIOAVAILABILITY OF LIPOPHILLIC DRUGS FROMSELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
%A GUPTA ROOP N1
%A GUPTA RAKESH AND RATHORE GARVENDRA SINGH*
%J International Journal of Drug Development & Research
%D 2009
%I Chauhan Publishers
%X Approximately 40 per cent of new drug candidates have poor water solubility and the oral delivery of such drugs isfrequently associated with implications of low bioavailability, high intra and inter-subject variability, and lack of doseproportionality. Bioavailability problem of lipophillic drugs can be solved by formation of Self-Micro Emulsifying DrugDelivery System (SMEDDS). SMEDDS appears to be a unique and industrially feasible approach to overcome theproblem of low oral bioavailability associated with the lipophillic drugs. Self-micro emulsifying formulations are mixturesof oils and surfactants, ideally isotropic, and sometimes containing co-solvents, which emulsify spontaneously to producefine oil-in-water emulsion when introduced into aqueous phase under conditions of gentle agitation. The digestive motilityof the stomach and intestine provide the agitation necessary for self-emulsification in vivo. This review describesSMEDDS as one of the important approaches to overcome the formulation difficulties of potent lipophillic drugs.
%K Oral delivery
%K Bioavailability
%K Lipophillic drugs
%K Self-Micro Emulsifying Drug delivery system.
%U http://www.ijddr.com/PDF/2.pdf