%0 Journal Article
%T Facilitation of Relational Learning in Schizophrenia
%A Elena A. Spieker
%A Jacqueline A. Griego
%A Robert S. Astur
%A Henry H. Holcomb
%A Laura M. Rowland
%J Behavioral Sciences
%D 2013
%I MDPI AG
%R 10.3390/bs3020206
%X Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training.
%K schizophrenia
%K relational learning
%K training
%K transverse patterning
%K hippocampus
%K medial temporal lobe
%K memory
%U http://www.mdpi.com/2076-328X/3/2/206