%0 Journal Article
%T Using the Initial Systolic Time Interval to assess cardiac autonomic function in Parkinson¡¯s disease
%A Jan H. Meijer
%A Eskeline Elbertse
%A Sanne Boesveldt
%A Henk W Berendse
%J Journal of Electrical Bioimpedance
%D 2011
%I University of Oslo
%R 10.5617/jeb.216
%X The Initial Systolic Time Interval (ISTI) has been defined as the time difference between the peak electrical and peak mechanical activity of the heart. ISTI is obtained from the electro-cardiogram and the impedance cardiogram. The response of ISTI while breathing at rest and to a deep breathing stimulus was studied in a group of patients suffering from Parkinson's disease (PD) and a group of healthy control subjects. ISTI showed substantial variability during these manoeuvres. The tests showed that the variability of RR and ISTI was substantially different between PD patients and controls. It is hypothesized that in PD patients the sympathetic system compensates for the loss of regulatory control function of the blood-pressure by the parasympathetic system. It is concluded that ISTI is a practical, additional and independent parameter that can be used to assist other tests in evaluating autonomic control of the heart in PD patients. doi:10.5617/jeb.216 J Electr Bioimp, vol. 2, pp. 98-101, 2011
%K Initial systolic time interval
%K Impedance cardiography
%K Parkinson¡¯s disease
%K cardiac autonomic function
%K sympathetic function
%U https://www.journals.uio.no/index.php/bioimpedance/article/view/216