%0 Journal Article
%T Anticancer Activity of Indigofera aspalathoides and Wedelia calendulaceae in Swiss Albino Mice
%A Malaya Gupta
%A Upal K.anti Mazumder
%A Pallab K. Haldar
%A Chandi C. Kandar
%J Iranian Journal of Pharmaceutical Research
%D 2007
%I School of Pharmacy, Shahid Beheshti University of Medical Sciences
%X The methanolic extracts of Indigofera aspalathoides (MEIA) and Wedelia calendulaceae (MEWC) were evaluated for their anticancer activity against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice. On day 1, the extract of Indigofera aspalathoides at a dose of 250 and 500 mg/kg body weight and the extract of Wedelia calendulaceae at a dose of 250 and 500 mg/kg body weight were administered orally and continued for 9 consecutive days. The anticancer activity of MEIA and MEWC were examined by determining the tumor volume, tumor cell count, viable tumor cell count, nonviable tumor cell count, mean survival time and increase in life span in experimental animal models. Both these extracts increased the life span of EAC treated mice and restored the hematological parameters as compared with the EAC bearing mice. Thus, the present study revealed that the MEIA and MEWC showed anticancer activityin the tested animal models.
%K Indigofera aspalathoides
%K Wedelia calendulaceae
%K Ehrlich acitic carcinoma
%K Anticancer
%U http://www.ijpr-online.com/docs/20072/IJPR321.pdf