%0 Journal Article
%T Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
%A Farzin Hadizadeh
%A Hossein Hosseinzadeh
%A Vahideh-Sadat Motamed-Shariaty
%A Mahmood Seifi
%J Iranian Journal of Pharmaceutical Research
%D 2008
%I School of Pharmacy, Shahid Beheshti University of Medical Sciences
%X Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobem-mide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alk-kylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepress-sant activity using forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively.
%K Imidazolecarboxamides
%K MAOIs
%K Antidepressant
%K Forced swimming model
%U http://www.ijpr-online.com/docs/20081/IJPR%20480.pdf