%0 Journal Article
%T Homozygous delta-beta Thalassemia in a Child: a Rare Cause of Elevated Fetal Hemoglobin
%A Verma S MD
%A Bhargava M MD
%A Mittal SK MD
%A Gupta R MD
%J Iranian Journal of Pediatric Hematology Oncology
%D 2013
%I Shahid Sadoughi University of Medical Sciences and Health Services
%X BackgroundDelta beta (¦Ä¦Â) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike ¦Â-thalassemia, show mild anemia. Only few cases of ¦Ä¦Â-thalassemia have been reported from India in the available indexed English literature.Case presentationA four-year old male child was evaluated for recent-onset jaundice. Hematological investigations showed mild anemia with microcytic hypochromic red cells. A comprehensive analysis of hemoglobin by high-performance liquid chromatography (HPLC) showed complete absence of HbA and HbA2 with HbF constituting 100% of the hemoglobin. Hemoglobin analysis of both parents showed elevated level of HbF with normal HbA2. A final diagnosis of ¦Ä¦Â-thalassemia in the child with both parents being carriers was rendered. ConclusionDelta beta-thalassemia is an uncommon cause of markedly elevated fetal hemoglobin beyond fetal period. Clinical and haematological parameters should be evaluated to render an accurate diagnosis.
%K Delta-Beta Thalassemia
%K Homozygote
%K Chromatography
%K High Pressure Liquid
%U http://85.185.157.11:6280/ijpho/browse.php?a_id=106&slc_lang=en&sid=1&ftxt=1