%0 Journal Article
%T Assessment Hepatomegaly and liver Enzymes in 100 Patients with beta Thalassemia Major in Mashhad, Iran
%A Hashemizadeh H
%A Noori R
%A kolagari SH
%J Iranian Journal of Pediatric Hematology Oncology
%D 2012
%I Shahid Sadoughi University of Medical Sciences and Health Services
%X BackgroundFrequent blood transfusion in patients with beta thalassemia major can lead to iron overloadespecially in liver. Chronic iron overload could cause cirrhosis of the liver. Transfusiontransmittedhepatitis B and C also could develop cirrhosis in individuals.Materials and MethodsThe present cross- sectional descriptive study is to assess hepatomegaly and liver enzymes in 100patients with beta thalassemia major, ages between 2-18 years old. The study was carried outretrospectively. One hundred medical records have chosen from 400 samples of thalassemiamajor patients, who are under a regular care of the department of sarvar clinic.ResultsOut of these patients, 55% were male and 45% female. The mean age of thalassemia patients was10.8 4.4 years. The mean and S. D of hemoglobin, ferritin, deferoxamine dosage was 8.5 ¡À1.5g/dl , 2183 ¡À 1528 ng , 30 ¡À 11.16 mg/kg, respectively. Forty six percent of them hadhepatomegaly. The mean and S. D of AST and ALT were 95¡À 70 IU/L and 70 ¡À35U/Lrespectively. Splenectomy was performed on 44% of patient.ConclusionHepatomegaly is one of the most common findings in the thalassemic patient that induced withhemosiderosis and hepatitis.
%K Epidemiology
%K Hepatomegaly
%K Liver
%K beta-Thalassemia
%U http://85.185.157.11:6280/ijpho/browse.php?a_id=92&slc_lang=en&sid=1&ftxt=1