%0 Journal Article
%T Preparation and biodistribution studies of 165Dy-FHMA for radiosynovectomy
%A Simindokht Shirvani-Arani
%A Amir Mahmoodabadi
%A Ali Bahrami-Samani
%A Mohammad Ghannadi-Maragheh
%J Iranian Journal of Nuclear Medicine
%D 2010
%I 
%X Introduction: Synovectomy is a method capable of easy removal of inflamed region of synovium by beta-radiation through the direct injection with radioactive materials labeled with beta-emitting radio nuclide. In the treatment of cancers or arthritis by radiation emitted from radioactive materials in the lesions, the administrated material to lesion should be retained only in the lesion, and not leaked from the lesion. One of the most effective approaches to retain the radionuclide in the administrated site is to prepare its ferric hydroxide macro aggregates. Methods: The preparation of 165Dy labeled FHMA (ferric hydroxide macro aggregate) for radiosynovectomy applications is described in this study. 165Dy was prepared by the irradiation of natural Dy (NO3)3.5H2O at a flux of 3-4 ¡Á 1013 neutrons/cm2/s for about 2 hours. The irradiation resulted in the production of 18.5 GBq (500 mCi) of 165Dy activity. At the end of 7 hours after bombardment the corresponding specific activity was 2.3 GBq/mg (62.5mCi/mg). The irradiated target was dissolved in 0.1 N HCl. Radionuclidic purity was ascertained by high resolution gamma-spectrometry. FeSO4 and Fe(N03)3 X 9H20 were dissolved in 0.1 M H2SO4 and diluted with H2O. Then NaOH were slowly added while shaking the vial. The resulted macro aggregates was labeled with 165Dy to prepare 165Dy -FHMA complex. Bio-evaluation of the prepared 165Dy -FHMA was carried out by injecting 37 MBq (1mCi) dose in 100 ¦Ìl directly into knee joints of wild type rats. The biodistribution studies were performed to investigate the leakage of the injected 165Dy -FHMA. Results: It was observed that there was no significant extra articular leakage of the injected activity over the study period of 10 h post injection. Conclusion: The produced 165Dy -FHMA properties suggest applying a new efficient synovectomy therapeutic agent in the country
%K Radiosynovectomy
%K Dy-165
%K FHMA
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16984.pdf&manuscript_id=16984