%0 Journal Article
%T Comparison of Tc-99m Ubiquicdin(UBI)29-41 and Tc-99m MDP scintigraphy in patients suspected to orthopedic infections before and after antibiotic therapy
%A Babak Nazari
%A Zahra Azizmohamadi
%A Morteza Rajaei
%A Babak Shafiei
%J Iranian Journal of Nuclear Medicine
%D 2010
%I 
%X Introduction: anionic microbial cell membrane, at the site of infection. Higher number of viable bacteria in site of infection results in higher UBI accumulation. The current study evaluates the potential ability of Tc-99m-UBI 29-41 to assessment of response to antibiotic therapy in orthopedic infection. Methods: 12 patient, 10 male and 2 female (mean age 41.6y; rang 23-75y) with suspected orthopedic infection (Bone, soft tissue or prosthesis) and positive UBI scan for infection were included in the study. One day after UBI scan; Bone scan was done as well. 9 of 12 patients underwent appropriate treatment including empirical antibiotics and three patient refuse treatments. After 10-14 day interval all patient divided in two groups: a) Responder to therapy and 2) No responder - None treated with respect to orthopedic specialist judgment. In all 12 patients ESR and CRP and in most of them specimen culture before and after 10-14 day interval was done. 3 patient of 4 non responder - non treated group underwent antibiotic therapy and was evaluated 10-14 day after again. One of these patient responded to recent therapy and two patient not. Thus, 15 cases were evaluated in this study that divided in two groups: a) nine Responder and b) six non responder - none treated. Results: Quantitative analysis of ESR, CRP and Bone scan before and after 10-14 day interval in two groups show no significantly change, But quantitative UBI scan in 30, 60 &120 minute after tracer injection indicates significantly reduction in tracer uptake after 10-14 day interval compared to UBI scan before this interval in responder group but changes not significant in non responder - non treated group. Conclusion: Quantitative UBI scan can determine response to antibiotic therapy in orthopedic infection in humans and with conjunction UBI scan and Bone scan we can rapidly diagnose orthopedic infection and determine that bony structure is involved or not.
%K Ubiquicdin(UBI) scintigraphy
%K MDP scintigraphy
%K Orthopedic infections
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16946.pdf&manuscript_id=16946