%0 Journal Article
%T Preparation and Quality Control of Scandium-46 Bleomycin as a Possible Therapeutic Agent
%A Leila Moghaddam-Banaem
%A Amir Reza Jalilian
%A Mohammadreza Pourjavid
%A Ali Bahrami-Samani
%J Iranian Journal of Nuclear Medicine
%D 2012
%I 
%X Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound. Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 กม 1013 n.cm-2.s-1) of natural metallic scandium sample followed by dissolution in acidic media as a substitute for 47Sc in radiolabeling studies which was further used for labeling of bleomycin (BLM) followed by stability studies as well as biodistribution in wild-type rats. Results: Sc-46 was obtained in high radiochemical purity (ITLC, >99%, two systems) as well as acceptable specific activity. At optimized conditions a radiochemical purity of 98% was obtained for 46Sc-BLM shown by ITLC (Specific activity, 740 GBq/mmole). The accumulation of the radiolabeled compound in lungs, liver and spleen demonstrates a similar pattern to the other radiolabeled bleomycins. Conclusion: Sc-BLM is a possible therapeutic agent in human malignancies and the efficacy of the compound should be tested in various tumor-bearing models.
%K Bleomycin
%K Sc-46
%K Biodistribution
%K Radiolabeling
%U http://irjnm.tums.ac.ir/?_action=showPDF&article=1208&_ob=7c52a1fc54c783a510bc10031a17d3c2&fileName=full_text.pdf