%0 Journal Article
%T Optical coherence tomography versus visual evoked potential in multiple sclerosis patients
%A Farzad Fatehi
%A Vahid Shaygannejad
%A Lida Kiani Mehr
%A Alireza Dehghani
%J Iranian Journal of Neurology
%D 2012
%I Tehran University of Medical Sciences
%X Background: Optical coherence tomography (OCT) is anon-invasive instrument, which can be used to estimate thethickness of the retinal nerve fibre layer (RNFL) and providesan indirect measurement of axonal destruction in multiplesclerosis (MS). The main aim of this study was to find out anycorrelations between P100 latency in visual evokedpotential (VEP) and RNFL thickness.Methods: The patients with the definite history of opticneuritis regardless of the diagnosis of MS were included. Theeyes with the history of blurred vision and increased VEPlatency (> 115 milliseconds) were considered as cases and theeyes with normal latency were regarded as controls. RNFLthickness was compared between two groups of cases andcontrols. In addition, the correlation between VEP P100latency and RNFL thickness in four quadrants of superior,nasal, inferior and temporal fields was estimated by spearmancorrelation coefficient. RNFL thickness between the patientswith history of clinically isolated syndrome (CIS) was alsocompared to other two subgroups of RRMS and SPMS.Results: There was significant negative correlationbetween VEP P100 latency and RNFL. In all fourquadrants, with increasing VEP latency, RNFL thicknessdecreased. Furthermore, there was significantcorrelation between P100 latencies and mean RNFLthickness [Pearson correlation coefficient = -0.527, P <0.001; RNFL (mean) = (-0.44 ¡À 0.087) ¡Á P100 + (153.6 ¡À10.94)]. Comparing RNFL thickness between threegroups of CIS, RRMS, and SPSM, no significant differencewas detected in RNFL thickness (P > 0.05). Power analysisdemonstrated that RNFL average had the highest areaunder curve.Conclusion: OCT does have good correlations with P100latency, indicating retinal non-myelinated axonalinvolvement in early stages in addition to themyelinated axonal involvement. However, it cannot beused as the sole test in evaluating visual pathway inoptic neuritis and complementary tests as VEPs arerecommended.
%K Optical Coherence Tomography
%K Multiple Sclerosis
%K Clinically Isolates Syndrome
%K Visual Evoked Potential
%U http://ijnl.tums.ac.ir/index.php/ijnl/article/view/86