%0 Journal Article
%T Production, quality control and biological evaluation of 153Sm-TTHMP as a possible bone palliation agent
%J Iranian Journal of Nuclear Medicine
%D 2011
%I 
%X Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents.Methods: 153Sm-TTHMP was prepared starting from 153Sm-SmCl3, prepared by neutron activation of an enriched 152Sm sample (purity >98%), and in-house synthesized TTHMP in 1h at 25ˇăC followed by stability tests, partition coefficient determination and biodistribution studies of in wild-type rodents using scarification and SPECT imaging.Results: The radiolabled Sm complex was prepared in high radiochemical purity (>99%, ITLC) and specific activity of 278 GBq/mmol and demonstrated significant stability at 4, 25 and 37ˇăC (in presence of human serum). Initial biodistribution data showed significant bone accumulation of the tracer in 48h.Conclusion: 153Sm-TTHMP can be a potential candidate for bone pain palliation therapy in skeletal metastases, although further biological studies in other mammals is still needed.
%K Sm-153
%K TTHMP
%K Radiopharmaceutical
%K Therapy
%K Biodistribution
%K Imaging
%U http://irjnm.tums.ac.ir/index.php/irjnm/article/view/712/668