%0 Journal Article
%T Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey
%A Anna Kotronen
%A Hannele Yki-J£¿rvinen
%A Satu M£¿nnist£¿
%A Liisa Saarikoski
%A Eeva Korpi-Hy£¿v£¿lti
%A Heikki Oksa
%A Juha Saltevo
%A Timo Saaristo
%A Jouko Sundvall
%A Jaakko Tuomilehto
%A Markku Peltonen
%J BMC Public Health
%D 2010
%I BioMed Central
%R 10.1186/1471-2458-10-237
%X The cohort included 2766 Finnish subjects (45-74 years) from the population-based FIN-D2D survey. Features of insulin resistance, components of the MetS, glucose tolerance status by oral glucose tolerance test, serum liver enzyme concentrations, and daily alcohol consumption were assessed.Subjects with NAFLD and AFLD were equally obese and had similar fasting and insulin concentrations. The prevalences of NAFLD and AFLD were 21% (95% CI: 19%-22%) and 7% (95% CI: 6%-8%). The MetS was slightly more prevalent in AFLD (73%) than in NAFLD (70%, p = 0.028), and type 2 diabetes was similarly prevalent in NAFLD and AFLD (24-25%). The MetS and type 2 diabetes were more prevalent in subjects with NAFLD or AFLD compared to subjects with normal LFTs (53% and 14%, p < 0.0001 for both).In Finnish middle-aged population, the prevalence of NAFLD is 3-fold higher than that of AFLD. The prevalences of MetS and type 2 diabetes are, however, significantly increased in both NAFLD and AFLD compared to subjects with normal LFTs. Subjects with AFLD are thus similarly metabolically unhealthy as subjects with NAFLD.Non-alcoholic fatty liver disease (NAFLD) is defined as a fatty liver (liver fat >5-10% of liver weight), which is not due to excess alcohol consumption or other causes of steatosis [1]. NAFLD is associated with obesity, the metabolic syndrome, dyslipidemia, insulin resistance, and type 2 diabetes [1]. NAFLD is the most common cause of elevated liver function tests (LFTs) in the US according to the NHANES III survey [2]. Population-based studies from the US have reported the prevalence of increased liver fat content to be 34% when measured using quantitative proton magnetic resonance spectroscopy [3] and ~20% when estimated using elevated LFTs [4,5]. However, excess alcohol consumption is common and could coexist with NAFLD. Merely focusing on NAFLD by excluding subjects using excessive amounts of alcohol may thus underestimate the prevalence of the MetS and type 2 diabetes in sub
%U http://www.biomedcentral.com/1471-2458/10/237