%0 Journal Article
%T Co-Infection With Syphilis and Malaria: Immune Deterioration on CD4+
%A Viroj Wiwanitkit
%J Iranian Journal of Medical Hypotheses & Ideas
%D 2008
%I Tehran University of Medical Sciences
%X Syphilis is a well-known sexually transmitted disease found around the world. Malaria and syphilis are endemic in many regions of the world, and co-infection with the two pathogens is common. Here, the author used a new pathway ontology technology to predict the pathway of CD4+ suppression in an episode of co-infection. Of interest, the author found that there are some immune suppression process that can be found both in syphilis and malaria. The mentioned processes are inhibiting interleukin-2 secreted by CD4+ and nitric oxide production. In the co-infection, the synergy to increase the immune suppression can be expected.
%K Syphilis
%K CD4+ suppression
%K Malaria
%K Function
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4592.pdf&manuscript_id=4592