%0 Journal Article
%T Comparison of Allergic Adverse Effects and Contrast Enhancement Between Iodixanol and Iopromide
%A Farideh Gharekhanloo
%A Saadat Torabian
%J Iranian Journal of Radiology
%D 2012
%I Tehran University of Medical Sciences
%X Background: Iodinated X-ray contrast media are the most commonly used contrastagents in the world with an annual application of 40-50 million. New non-ionic contrastagents are subdivided into low osmolar agents such as iopromide and iso-osmolaragents such as iodixanol. Regarding different biochemical characteristics, these agentsare different in the allergic reactions and contrast enhancement and final lesion conspicuity.Objectives: This study was carried out to compare allergic adverse effects and contrastenhancement between iodixanol and iopromide.Patients and Methods: One-hundred and twenty patients who were referred for abdominalCT scan to Besat Hospital were included in this study. Patients were randomly dividedinto two groups (A & B). Group A received 100 cc iodixanol (300 mgI/mL) and group B received100 cc iopromide (300 mgI/ml) by power injector. CT examination was performedusing Helical CT Scanner (Somatom, Siemens, Germany). Sixty seconds after injection,images were obtained and enhancement of port, liver and aorta were determined. Allergicadverse effects were recorded one hour and up to one week after injection.Results: Iodixanol produced a significantly greater enhancement of the hepatic, aortaand portal vein than iopromide (P < 0.01). Sixty seconds after injection, associated painand heat sensation were less frequent in iodixanol in comparison with iopromide (P =0.03). Immediate reactions such as nausea and vomiting were less frequent in iodixanol(P = 0.01). Late skin reactions such as rash was more frequent in iodixanol (P < 0.01).Conclusions: Iodixanol is safe and is better tolerated in the early phase of injection withbetter contrast enhancement and lesion conspicuity. Mild late skin rash is its disadvantage.
%K Iodixanol
%K Iopromide
%K Hypersensitivity
%U http://iranjradiol.com/?page=download&file_id=10007