%0 Journal Article
%T Detection of Rare and Unknown Mutations in  - tathalassemia Traits in Iran
%A M Habibi Roudknar
%A H Najmabadi
%A P Derakhshandeh
%A DD Farhud
%J Iranian Journal of Public Health
%D 2003
%I Tehran University of Medical Sciences
%X Beta-thalassemia, by its high frequency and heterogenecity, constitues a real problem of health in Iran. Aboute 13 beta globin mutations encompass 70-90% of mutations spectrum in Iran, the rest are rare or unknown. In this study six mutations of the codon IVSI-130(G-C), Fr16 (-C), codon35 (-C), fr23/24(-G), codon8 (+G) and codon 20 (GTG-GAG) were recognized and added to spectrom of beta globin mutations in Iran, Using ARMS/PCR and DNA sequencing. Three latter cases are reported for first time.
%K Beta-thalassemia
%K Unknown mutations
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/286.pdf&manuscript_id=286