%0 Journal Article
%T Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India
%A Rashmi Sinha
%A Carrie R Daniel
%A Niveditha Devasenapathy
%A Hemali Shetty
%A Susan Yurgalevitch
%A Leah M Ferrucci
%A Preethi S George
%A Kerry Morrissey
%A Lakshmy Ramakrishnan
%A Barry I Graubard
%A Kavita Kapur
%A K Reddy
%A Mary J McAdams
%A Tanuja Rastogi
%A Nilanjan Chatterjee
%A Prakash C Gupta
%A Sholom Wacholder
%A Dorairaj Prabhakaran
%A Aleyamma A Mathew
%J BMC Public Health
%D 2011
%I BioMed Central
%R 10.1186/1471-2458-11-405
%X Field staff contacted 7,064 households within three regions of India (New Delhi, Mumbai, and Trivandrum) and found 4,671 eligible adults aged 35-69 years. Participants completed interviewer-administered questionnaires (demographic, diet history, physical activity, medical/reproductive history, tobacco/alcohol use, and occupational history), and staff collected biological samples (blood, urine, and toenail clippings), anthropometric measurements (weight, standing and sitting height; waist, hip, and thigh circumference; triceps, sub-scapula and supra-patella skin fold), and blood pressure measurements.Eighty-eight percent of eligible subjects completed all questionnaires and 67% provided biological samples. Unique protein sources by region were fish in Trivandrum, dairy in New Delhi, and pulses (legumes) in Mumbai. Consumption of meat, alcohol, fast food, and soft drinks was scarce in all three regions. A large percentage of the participants were centrally obese and had elevated blood glucose levels. New Delhi participants were also the least physically active and had elevated lipids levels, suggesting a high prevalence of metabolic syndrome.A high percentage of participants complied with study procedures including biological sample collection. Epidemiologic expertise and sufficient infrastructure exists at these three sites in India to successfully carry out a modest sized population-based study; however, we identified some potential problems in conducting a cohort study, such as limited number of facilities to handle biological samples.According to the World Health Organization, cancer deaths in India are expected to increase 158% by the year 2020. Although overall actual cancer incidence rates are lower in India than in North America and Europe, the rise in cancer-related deaths is likely to present a significant burden to the already overwhelmed health systems. Unique environmental exposures, as well as the genetic variation among people in India, can provide valu
%U http://www.biomedcentral.com/1471-2458/11/405