%0 Journal Article
%T Report on the 3'rd scientific meeting of the "Verein zur F£¿rderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011
%A Christoph Kleinschnitz
%A Sven G Meuth
%A Tim Magnus
%A Thomas Korn
%A Ralf A Linker
%A on behalf of the speakers at the 3'rd NEUROWIND e.V. scientific meeting
%J Experimental & Translational Stroke Medicine
%D 2012
%I BioMed Central
%R 10.1186/2040-7378-4-2
%X In 2011, presentations in the field of neuroimmunology dealt with multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-mediated diseases (stiff-person-syndrome - SPS, Batten disease, neuromyelitis optica - NMO, limbic encephalitis) and Shiga toxin (Stx)-producing Escherichia coli (STEC) infection.Anne Willing from Manuel Friese's lab in Hamburg demonstrated that IL-17 production by CD8+ T cells is mainly restricted to CD161 high cells. In MS patients, CD4 + CD161+ cells are significantly increased in the CSF. In contrast CD161 high CD8+ cells belonging to mucosal associated invariant T cells (MAIT) reacting to bacteria but not viruses are significantly reduced in peripheral blood and CSF in MS.Christina Heinemann from Thomas Korn's laboratory in Munich investigated the role IL-23 in the priming of encephalitogenic T helper cell responses. Using IL-23R knockout mice, she found that a major T cell intrinsic function of IL-23 is the suppression of IL-10. Thus, an overwhelming IL-10 response rather than the lack of Th17 cells in IL-23R KO mice confers resistance to EAE in these animals.The importance of microRNAs in neuroinflammation was highlighted by Andreas Junker from G£¿ttingen. 172 from 365 tested microRNAs were detected in inactive MS lesions. Conversely, Andreas showed that microRNA-155 was overexpressed in active MS lesions and microRNA155 deficient mice demonstrated an ameliorated EAE disease course.Another EAE project was presented by Arndt Manzel from Ralf Linker's group in Erlangen. Arndt investigated the role of the sodium/fluid balance in T cell responses. Together with recent data on the role of the renin angiotensin system in autoimmune inflammation, these results further underscore the notion that key players in renal function may also impact on immune responses.Catherina Sorbara from Martin Kerschensteiner's group in Munich demonstrated the importance of axonal damage for sustained disability progression in MS pat
%U http://www.etsmjournal.com/content/4/1/2