%0 Journal Article
%T Early diagnostic markers of sepsis after oesophagectomy (including thromboelastography)
%A Miroslav Durila
%A Jiˋ赤 Bronsky
%A Tom芍ˋ Haruˋtiak
%A Alexander Pazdro
%A Marta Pechov芍
%A Karel Cvachovec
%J BMC Anesthesiology
%D 2012
%I BioMed Central
%R 10.1186/1471-2253-12-12
%X We enrolled 43 patients (aged 41每74ˋyears) of whom 38 were evaluable. Blood samples were obtained on the morning of surgery and then at 24-hour intervals for the next 6ˋdays. Samples were analysed for procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL- 6), aspartate transaminase (AST), alanine transaminase (ALT) , lactate, white blood count (WBC), D-dimers, antithrombin (AT), international normalised ratio (INR), activated partial thromboplastin time (APTT) and parameters of TEG.Significant differences between patients who developed sepsis during this period (9 patients) and SIRS were found in ALT on Day 1, in AST on Days 1每4, in PCT on Days 2每6; in CRP on Days 3每6; in IL-6 on Days 2每5; in leucocytes on Days 2, 3 and 6; and in D-dimers on Days 2 and 4. Significance values ranged from pˋ<ˋ0.0001 to pˋ<ˋ0.05.Sequential measurements of ALT, AST, PCT and IL-6 during the early postoperative period can be used for early differentiation of sepsis and postoperative SIRS after oesophagectomy. Among the coagulation parameters measured, only D-dimer concentrations appeared to be helpful in this process. TEG does not seem to be a useful early predictor of sepsis development; however it can be used to differentiate sepsis and SIRS from Day 5 after surgery.
%K Sepsis
%K Biochemical
%K Hematological
%K Thromboelastography
%U http://www.biomedcentral.com/1471-2253/12/12/abstract