%0 Journal Article
%T Rapid assessment of Hib disease burden in Vietnam
%A Batmunkh Nyambat
%A Duc Dang
%A Hien Nguyen
%A Trinh Mai
%A Manju Rani
%A Mary PE Slack
%A Paul E Kilgore
%J BMC Public Health
%D 2011
%I BioMed Central
%R 10.1186/1471-2458-11-260
%X Laboratory, hospitalization and mortality data were collected for the period January 2004 through December 2005 from five representative hospitals. Based on the WHO Hib RAT protocol, standardized MS Excel spreadsheets were completed to generate meningitis and pneumonia case and death figures.We found 35 to 77 Hib meningitis deaths and 441 to 957 Hib pneumonia deaths among children < 5 years of age annually in Vietnam. Overall, the incidence of Hib meningitis was estimated at 18/100,000 (95% confidence interval, CI, 15.1-21.6). The estimated Hib meningitis incidence in children < 5 years age was higher in Ho Chi Minh City (22.5/100,000 [95% CI, 18.4-27.5]) compared to Hanoi (9.8/100,000 [95% CI, 6.5-14.8]). The Hib RAT suggests that there are a total of 883 to 1,915 cases of Hib meningitis and 4,414 to 9,574 cases of Hib pneumonia per year in Vietnam.In Hanoi, the estimated incidence of Hib meningitis for children < 5 years of age was similar to that described in previous population-based studies of Hib meningitis conducted from 1999 through 2002. Results from the Hib RAT suggest that there is a substantial, yet unmeasured, disease burden associated with Hib pneumonia in Vietnamese children.Prior to the introduction of universal childhood immunization with Haemophilus influenzae type b (Hib) vaccine, Hib was the most common cause of life-threatening bacterial infection (most often resulting in meningitis, bacterial pneumonia, and sepsis) in young children in industrialized countries [1]. Haemophilus influenzae, including Hib, is a well-known cause of childhood and adult disease with manifestations that include pneumonia, meningitis, epiglottitis, empyema, septicemia, septic arthritis, osteomyelitis, pericarditis, and cellulitis [2,3]. Globally, Hib is responsible for an estimated 3 million cases of serious disease and 386,000 childhood deaths every year [4]. Since the introduction of Hib conjugate vaccines in many countries, the decline in Hib disease burden has been
%K Hib
%K vaccine
%K RAT
%K disease burden
%U http://www.biomedcentral.com/1471-2458/11/260