%0 Journal Article %T Biological effects of exposure to magnetic resonance imaging: an overview %A Domenico Formica %A Sergio Silvestri %J BioMedical Engineering OnLine %D 2004 %I BioMed Central %R 10.1186/1475-925x-3-11 %X Safety issues and discussions about potential hazards associated with magnetic resonance imaging (MRI) systems and procedures have been extremely controversial over the past decade: partly because of the disputed assertions about the role of electromagnetic fields in carcinogenesis or the promotion of abnormalities in growth and development [1-3]; partly because the assumption that MRI was inherently a safe procedure had reduced the importance of the publication of negative results [4]. Since the introduction of MRI as a clinical modality in the early 1980s, more than 100,000,000 diagnostic procedures (estimated) have been completed worldwide, with relatively few major incidents [5,6].Most reported cases of MRI related injuries have been caused by misinformation related to the MR safety aspects of metallic objects, implants, and biomedical devices [7,8]. In fact, the MR environment may be unsafe for patients with certain implants, primarily due to movement or dislodgment of objects made from ferromagnetic materials [9], but also because of heating and induction of electrical currents, which may present risks to patients with implants or external devices [10]. These safety problems are typically associated with implants that have elongated configurations or that are electronically activated (e.g. neurostimulation systems, cardiac pacemakers, etc.). In the MR environment, magnetic field-related translational attraction and torque may cause hazards to patients and individuals with such implants. The risks are proportional to the strength of the static magnetic field, the strength of the spatial gradient, the mass of the object, its shape and its magnetic susceptibility. Furthermore, the intended in vivo use of the implant or device must be taken into consideration because existing counteracting forces may be present that effectively prevent movement or dislodgment of the object. To date, more than one thousand implants and objects have been tested for MR safety or comp %U http://www.biomedical-engineering-online.com/content/3/1/11