%0 Journal Article
%T Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case¨Ccontrol study in the Canary Islands (Spain)
%A Luis D Boada
%A Manuel Zumbado
%A Luis Henr¨ªquez-Hern¨¢ndez
%A Maira Almeida-Gonz¨¢lez
%A Eva E ¨¢lvarez-Le¨®n
%A Lluis Serra-Majem
%A Octavio P Luzardo
%J Environmental Health
%D 2012
%I BioMed Central
%R 10.1186/1476-069x-11-28
%X This population-based study was designed to evaluate the profile of mixtures of organochlorines detected in 103 healthy women and 121 women diagnosed with breast cancer from Gran Canaria Island, and the relation between the exposure to these compounds and breast cancer risk.The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women. Breast cancer patients presented more frequently a combination of aldrin, dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD), and this mixture was not found in any healthy woman. After adjusting for covariables, the risk of breast cancer was moderately associated with DDD (OR£¿=£¿1.008, confidence interval 95% 1.001-1.015, p£¿=£¿0.024).This study indicates that healthy women show a very different profile of organochlorine pesticide mixtures than breast cancer patients, suggesting that organochlorine pesticide mixtures could play a relevant role in breast cancer risk.Breast cancer (BC) is the most common cancer diagnosed in women worldwide [1]. In Spain, BC is currently the most significant cause of death from malignancies in women [2]. Whereas BC mortality and incidence are lower in mainland Spain than in other European countries, there are alarming rates of mortality because of this type of cancer in the archipelago of the Canary Islands, specifically in Gran Canaria Island (Figure£¿1) [3,4].The etiology of BC is complex, with genetic, epigenetic and environmental factors contributing to the development of the disease. BC risk is significantly influenced by genetics, but over 70% of the women that are diagnosed have sporadic cancer or tumours not associated with inheritance of any major identified high risk genes. It is thought that the risk of BC can be modified by lifestyle and environment. Besides the genetic influence, the most established factors contributing to BC are related to cumulative exposure of t
%K Breast cancer risk
%K Organochlorine pesticides mixtures
%K Dichlorodiphenyldichloroethane (DDD)
%U http://www.ehjournal.net/content/11/1/28