%0 Journal Article
%T Ocular lesions in 1,000 consecutive HIV-positive patients in India: a long-term study
%A Sridharan Sudharshan
%A Sheikh Kaleemunnisha
%A Akbar Ashraf Banu
%A Sankaran Shrikrishna
%A Amala E George
%A B Rajesh Babu
%A Bella Devaleenal
%A Nagalingeshwaran Kumarasamy
%A Jyotirmay Biswas
%J Journal of Ophthalmic Inflammation and Infection
%D 2013
%I Springer
%R 10.1186/1869-5760-3-2
%X Age range of the patients was 1.5 to 75 years. Ocular lesions were seen in 68.5% of the patients (cytomegalovirus (CMV) retinitis was the commonest). The commonest systemic disease was pulmonary TB. Mean interval between HIV diagnosis and onset of ocular lesions was 2.43 years. CD4 counts range from 2 to 1,110 cells/mm3. Immune recovery uveitis (IRU) was seen in 17.4%. Interval between HAART initiation and IRU was 4 months to 2.5 years. Recurrence of ocular infection was seen in 2.53% (post-HAART) and >£¿20% (pre-HAART). Overall visual outcome showed improvement in about 14.3% and was maintained in 71.6% of the patients.CMV retinitis is the commonest ocular opportunistic infection in India, even in the HAART era. Newer manifestations of known diseases and newer ocular lesions are being seen. In contrast to Western studies, in our patients on HAART, ocular lesions do not always behave as in immunocompetent individuals. Ocular TB needs to be kept in mind in India, as well as other neuro-ophthalmic manifestations related to cryptococci, especially in gravely ill patients. Occurrence and frequency of various ocular opportunistic infections in developing nations such as India have significant variations from those reported in Western literature and need to be managed accordingly.Ocular lesions attributable to HIV [1] are seen in upto 2/3rd of the estimated 2.5 million HIV-positive population [2] in India at some point in their lifetime.Ocular lesions in patients on highly active antiretroviral therapy (HAART) have shown changes in disease prevalence and pattern and have been described in the Western population. Ocular lesions associated with AIDS in India have been described in the past during the pre-HAART era [3-9]. There are not many long-term studies on ocular lesions of HIV-positive patients in relation to HAART, especially in developing nations such as India. We studied the ocular lesions and systemic correlation of 1,000 consecutive patients with HIV in India espec
%K HIV
%K AIDS
%K Immune recovery uveitis
%K CMV retinitis
%K Ocular lesions
%K CMV retinitis
%K Ocular TB
%U http://www.joii-journal.com/content/3/1/2