%0 Journal Article
%T Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?
%A Fouad El Sayed
%A Rola Dhaybi
%A Alfred Ammoury
%A Myrna Chababi
%J Head & Face Medicine
%D 2006
%I BioMed Central
%R 10.1186/1746-160x-2-32
%X We report a 32-year-old man presenting with multiple nodules on the cheeks, preauricular region and the scalp and who received treatment with isotretinoin (0.5 mg/kg/day) for 1 year with complete resolution of one of his scalp nodules. The rest of the lesions remained stable and were treated with surgical excision without recurrence.Isotretinoin may play a role in the treatment of ALHE due to its antiangiogenic properties via a reduction of vascular endothelial growth factor (VEGF) production by keratinocytes.Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region. Spontaneous regression is common, but persistent or recurrent lesions may require treatment [1]. Several treatments have been reported but surgery is the most efficient. We report a new case of ALHE and discuss the efficiency of treatment with isotretinoin.A 32-year-old white man had multiple, pruritic and erythematous nodules on the cheeks, right preauricular region and scalp for 4 years. The lesions increased in number and size throughout these 4 years without spontaneous remission of any of them. The patient was seen by another physician 1 year prior to presentation, was considered to have acne conglobata and received treatment with isotretinoin (0.5 mg/kg/day) for one year. He initially had 2 scalp nodules, 2 nodules on the cheek and 2 in the preauricular region. The disease remained stable during treatment without new lesions. However, there was a complete regression of one of the scalp nodules, the remaining nodules decreased in size but didn't resolve. The improvement was noted within the first 4 months of treatment. Liver function tests and lipid profile remained normal throughout the treatment and he only complained from the common side effects of isotretinoin. At the time of presentation, physical examination revealed 2 erythematous to violaceo
%U http://www.head-face-med.com/content/2/1/32