%0 Journal Article
%T Collagenofibrotic Glomerulopathy: Three Case Reports in Brazil
%A Renata DR Ferreira
%A Fabiano B Cust¨®dio
%A Camila SO Guimar£¿es
%A Rosana RM Corr¨ºa
%A Marlene A Reis
%J Diagnostic Pathology
%D 2009
%I BioMed Central
%R 10.1186/1746-1596-4-33
%X We describe three patients that presented some factors in common, such as sex, age and the presence of non-nephrotic proteinuria associated with microscopic hematuria. The findings with the immunofluorescence microscopy, of immunoglobulins, and components of the complement were usually negative. The picrosyrius staining showed the presence of reddish material in the mesangium, when it was seen under standard microscopy; however, when it was seen with birefringence, it became greenish under polarized light, showed the collagen found in this area of the glomerulus. The identification of CG was made through electronic microscopic scanning, and curved and disorganized fibers were found.These cases are the first from South America to be reported, and they are about an idiopathic renal disease that is not related to any specific races or locations. The reports contribute to a better understanding of this disease, which although not so prevalent, should be considered as an importantly differential diagnostic of cases of proteinuria.Collagenofibrotic Glomerulopathy (CG) is a rare and recently defined entity characterized by deposition in the mesangial glomerulus and in the subendothelial space of type III collagen fibers [1]. It clinically manifests itself with proteinuria, hematuria, hypertension and variable degrees of renal failure in adults and children [2,3].Type III collagen inside the basal membrane of the glomeruli is already part of the identification of another disease, known as Nail-Patella Syndrome. This syndrome is characterized by bone and nail abnormalities, associated with proteinuria of variable degrees. Publication of articles related to this new entity began in the late 70's, and it was made by a team of Japanese doctors who considered this disease to be either a variation of Nail-Patella Syndrome or a completely new one [4].Based on the archive of renal biopsies at Nephopathology Service at General Pathology at the Federal University of Triangulo Mineiro
%U http://www.diagnosticpathology.org/content/4/1/33