%0 Journal Article
%T A case of non-invasive serous adenocarcinoma at unilateral fimbria with spread to the peritoneal/uterine cavity: case report
%A Yuki Fukumura
%A Akiko Masaoka
%A Toshio Naito
%A Miki Kimura
%A Takashi Yao
%J Diagnostic Pathology
%D 2009
%I BioMed Central
%R 10.1186/1746-1596-4-43
%X Pelvic serous carcinoma (PSC) has been presumed to arise in three different locations in the female pelvis [1]: the ovary (serous ovarian carcinoma), the endosalpinx (serous fallopian tube carcinoma) and on the peritoneal surface (primary peritoneal serous carcinoma). Among the three, primary cancer of the fallopian tube has previously been estimated to be very rare [2].Recently, tubal fimbriae have been shown as the common site for early PSC (intraepithelial carcinoma) in women with BRCA mutations [3]. Also, the potential role of the fimbriae in primary PSC has been suggested [4,5], irrespective of BRCA-status. A few case of fimbrial adenocarcinoma, though invasive, has also been reported in surgical material resected for benign gynecological tumor at other sites [6].We present a case of PSC caused by non-invasive serous adenocarcinoma involving the unilateral fimbria. To our knowledge, this is the first case report describing non-invasive, serous adenocarcinoma originating in the fimbria and spreading to the pelvic/intrauterine cavity in a clinical situation.A 67-year-old Japanese women, gravida 2, para 2, visited our hospital for regular (once 2 years) gynecologic screening. She had no family history for ovarian/breast carcinoma. There were no remarkable findings on physical examination/trans-vaginal ultrasonography. Endometrial cytology demonstrated abundant nests of adenocarcinomatous cells with peripherally located nuclei among sheets of non-atypical endometrial cells (Fig. 1A). Endometrial biopsy resulted in insufficient materials with only a few atypical cells. Abdominopelvic CT/MRI did not show enlargement of bilateral adnexa, endometrial thickenings lymphadenopathy, or ascites. Blood tests including tumor markers, CA125, CA19-9, and CEA were all within normal limits.Because of the cytology/biopsy findings, hysterectomy and bilateral salphingo-oophorectomy with sampling of intra - pelvic lymph nodes were performed. During surgery, there were no visible lesi
%U http://www.diagnosticpathology.org/content/4/1/43