%0 Journal Article
%T Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis
%A Leandro de Matos
%A Adriana Del Giglio
%A Carolina Matsubayashi
%A Michelle de Lima Farah
%A Auro Del Giglio
%A Maria da Silva Pinhal
%J Diagnostic Pathology
%D 2012
%I BioMed Central
%R 10.1186/1746-1596-7-97
%X A systematic review of published articles on MEDLINE and The Cochrane Library was performed. After establishing inclusion and exclusion criteria, 66 articles were selected. The technique of meta-analysis of diagnostic accuracy was employed and global values of sensitivity, specificity, area under the summary ROC curve, and diagnostic odds ratio (dOR) were calculated.For the immunohistochemistry technique, the positivity of CK-19 for the diagnosis of malignant thyroid lesions demonstrated global sensitivity of 81% and specificity of 73%; for Gal-3, sensitivity of 82% and specificity of 81%; and for HBME-1, sensitivity of 77% and specificity of 83%. The association of the three markers determined sensitivity of 85%, specificity of 97%, and diagnostic odds ratio of 95.1. Similar results were also found for the immunocytochemistry assay.This meta-analysis demonstrated that the three immunomarkers studied are accurate in pre- and postoperative diagnosis of benign and malignant thyroid lesions. Nevertheless, the search for other molecular markers must continue in order to enhance this diagnostic accuracy since the results found still show a persistency of false-negative and false-positive tests.Http://www.diagnosticpathology.diagnomx.eu/vs/3436263067345159Thyroid gland carcinoma is a very prevalent neoplasia worldwide. A survey sponsored by the World Health Organization (WHO) in 2010 revealed that there are around 44,670 new cases and 1,690 deaths caused by this disease every year [1].The majority of malignant lesions of the thyroid, such as papillary carcinoma, medullary carcinoma and undifferentiated histological types, can be diagnosed by cytological criteria using samples obtained by fine-needle aspiration biopsy (FNAB) guided by ultrasonography [2]. Likewise, the diagnosis of benign lesions, such as hyperplastic nodules, colloid nodules and auto-immune diseases like thyroiditis, can be cytologically established [3]. However, to distinguish between malignant and benig
%K Tumor markers
%K Biological
%K Galectin 3
%K Keratin 19
%K HBME-1 antigen
%K Thyroid
%K Review
%U http://www.diagnosticpathology.org/content/7/1/97