%0 Journal Article
%T Adamantinoma: A clinicopathological review and update
%A Deepali Jain
%A Vijay K Jain
%A Rakesh K Vasishta
%A Prabhat Ranjan
%A Yashwant Kumar
%J Diagnostic Pathology
%D 2008
%I BioMed Central
%R 10.1186/1746-1596-3-8
%X Adamantinoma is a primary low-grade, malignant bone tumor, of unknown histogenesis. However recent opinion seems to suggest that adamantinoma is a tumor of epithelial origin, based on ultrastructural and immunohistochemical studies [1]. The tumor is located predominantly in the mid-portion of the tibia. The cases do occur simultaneously in tibia and in adjacent fibula or may occur in fibula with out involvement of tibia. It is a rare neoplasm, comprise only 0.1¨C0.5% of all primary bone tumors [2]. The first reported example is attributed to Maier in 1900 [3]. In 1913, Fischer [4] named the lesion "primary adamantinoma of the tibia" because of its striking histologic resemblance to the jaw "adamantinoma" (ameloblastoma). In 1951, Schulenberg [5] suggested a unifying histogenetic concept for the adamantinomas of the appendicular skeleton.In the past there has been much speculation about the origin of adamantinoma. Several hypotheses have been proposed for its histogenesis [4,6-22] (Table 1). Fischer [4] has suggested congenital implantation of epithelial cells whilst Ryrie [6] and Dockerty and Meyerding [7] favoured traumatic implantation. These suggestions have been criticized by Lederer and Sinclair [9], and Naji [10], who suggested a synovial origin. Although vascularity is not a striking feature of this tumor, at times these tumors can be very vascular, and it is the vascularity which is responsible for the fact that some authors regard these tumors as angioblastomas [11-14]. The etiology of the tumors is still a matter of debate but the most widely adopted theory is that of displacement of basal epithelium of skin during embryological development and is supported by the predominant involvement of anterior tibia, where enchondrally formed bone is closest to the skin surface [2]. It seems to suggest that adamantinoma is a tumor of epithelial origin. Based on ultrastructural and immunohistochemical studies, the tumor cells show strong positive staining with pan-cyto
%U http://www.diagnosticpathology.org/content/3/1/8