%0 Journal Article
%T Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study
%A Camila Furtado de Souza
%A M¨¦riane Dalzochio
%A Francisco Jorge de Oliveira
%A Jorge Gross
%A Cristiane Leit£¿o
%J Diabetology & Metabolic Syndrome
%D 2012
%I BioMed Central
%R 10.1186/1758-5996-4-25
%X A prospective cohort study was conducted with subjects regularly attending the primary care unit of Hospital de Cl¨ªnicas de Porto Alegre. Participants underwent a 75£¿g OGTT. Metabolic syndrome definition was based on the criteria of IDF/AHA/NHLBI-2010.Participants mean age was 61£¿¡À£¿12£¿years (males: 38%; whites: 67%). Of the 148 subjects included, 127 (86%) were followed for 36£¿¡À£¿14£¿months, 21 (14%) were lost. Subjects were classified into four groups based on baseline OGTT: 29% normal (n£¿=£¿43), 28% impaired fasting glucose (IFG; n£¿=£¿42), 26% impaired glucose tolerance (IGT; n£¿=£¿38), and 17% diabetes (n£¿=£¿25). Metabolic syndrome prevalence was lower in normal group (28%), intermediate in IFG (62%) and IGT (65%) groups, and higher among subjects with diabetes (92%; P <0.001). Incidence of diabetes increased along with the stages of glucose metabolism disturbance (normal: 0%, IFG: 16%, IGT: 28%; P£¿=£¿0.004). No patient with normal OGTT developed diabetes, regardless metabolic syndrome presence. Diabetes at baseline was the major determinant of cardiovascular disease occurrence (normal: 0%, IFG: 4%, IGT: 0%, diabetes: 24%; P£¿=£¿0.001). In Cox-regression analysis, only the 2£¿h OGTT results were associated with diabetes (OR£¿=£¿1.03; 95%CI 1.01¨C1.06; P <0.001) and cardiovascular disease development (OR£¿=£¿1.013; 95%CI 1.002¨C1.025; P£¿=£¿0.024).In this sample of subjects undergoing diabetes screening, the OGTT predicted diabetes and cardiovascular disease more effectively than the metabolic syndrome status.Hyperglycemia is a well-known risk factor for micro- and macrovascular disease [1] and is associated with increased morbidity and mortality [2,3]. Alterations on glucose homeostasis have been described preceding diabetes mellitus (DM) diagnosis, and are known as ¡°prediabetes¡±. Prediabetes comprises two subcategories, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), classified based on glucose levels at fasting and after a glucose challenge (oral glucose tole
%K impaired fasting glucose
%K impaired glucose tolerance
%K type 2 diabetes
%K metabolic syndrome
%K cardiovascular disease
%U http://www.dmsjournal.com/content/4/1/25