%0 Journal Article
%T Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder
%A Subin Park
%A Jae-Won Kim
%A Young-Hui Yang
%A Soon-Beom Hong
%A Min-Hyeon Park
%A Boong-Nyun Kim
%A Min-Sup Shin
%A Hee-Jeong Yoo
%A Soo-Churl Cho
%J Behavioral and Brain Functions
%D 2012
%I BioMed Central
%R 10.1186/1744-9081-8-22
%X Fifty-three medication-na£¿ve children with ADHD were genotyped and evaluated using the continuous performance test (CPT). After 8-weeks of methylphenidate treatment, these children were evaluated by CPT again. We compared the baseline CPT measures and the post-treatment changes in the CPT measures based on the G1287A and the A-3081T polymorphisms of SLC6A2.There was no significant difference in the baseline CPT measures associated with the G1287A or A-3081T polymorphisms. After medication, however, ADHD subjects with the G/G genotype at the G1287A polymorphism showed a greater decrease in the mean omission error scores (p£¿=£¿0.006) than subjects with the G/A or A/A genotypes, and subjects with the T allele at the A-3081T polymorphism (T/T or A/T) showed a greater decrease in the mean commission error scores (p£¿=£¿0.003) than those with the A/A genotypes.Our results provide evidence for the possible role of the G1287A and A-3081T genotypes of SLC6A2 in methylphenidate-induced improvement in attentional performance and support the noradrenergic hypothesis for the pathophysiology of ADHD.
%K SLC6A2
%K Polymorphism
%K Continuous performance test
%K Methylphenidate
%U http://www.behavioralandbrainfunctions.com/content/8/1/22/abstract