%0 Journal Article
%T The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial
%A Masoume Mansouri
%A Neda Nayebi
%A Abasali keshtkar
%A Shirin Hasani-Ranjbar
%A Eghbal Taheri
%A Bagher Larijani
%J DARU Journal of Pharmaceutical Sciences
%D 2012
%I BioMed Central
%R 10.1186/2008-2231-20-47
%X A double-blind, randomized, placebo-controlled trial using a parallel design was conducted. 24 subjects who had metabolic syndrome diagnostic criteria (update of ATP III) were randomly assigned to either dill extract (n£¿=£¿12) or placebo (n£¿=£¿12) for 3 months.Across lipid component of metabolic syndrome, no significant differences in triglyceride (TG) concentration and high density lipoprotein cholesterol were seen between the two groups. However TG improved significantly from baseline (257.0 vs. 201.5p£¿=£¿0.01) with dill treatment but such a significant effect was not observed in placebo group. Moreover, no significant differences in waist circumference, blood pressure and fasting blood sugar were seen between two groups after 3 months follow up period.In this small clinical trial in patients with metabolic syndrome, 12 weeks of dill extract treatment had a beneficial effect in terms of reducing TG from baseline. However dill treatment was not associated with a significant improvement in metabolic syndrome related markers compared to control group. Larger studies might be required to prove the efficacy and safety of long-term administration of dill to resolve metabolic syndrome components.The clustering of metabolic abnormalities defined as metabolic syndrome does occur in one quarter of the world¡¯s adults. People with metabolic syndrome are three times as likely to have a heart attack or stroke compared with people without the syndrome and have a five-fold greater risk of developing type 2 diabetes [1].While metabolic syndrome causes the two global epidemics of type 2 diabetes and cardiovascular disease (CVD), it overpowers any effort to identify and treat those individuals with metabolic syndrome early, so that new and effective treatment methods may prevent the development of diabetes and/or CVD [1].Although, complementary and alternative therapies have long been used in the Eastern world, interest to herbal medicine along with the isolation and standardization of
%K Anethum graveolens
%K Dill
%K Metabolic syndrome
%K Hyperlipidemia
%K Clinical trial
%K Abdominal obesity
%U http://www.darujps.com/content/20/1/47