%0 Journal Article
%T Effects of tight versus non tight control of metabolic acidosis on early renal function after kidney transplantation
%A Farhad Etezadi
%A Pejman Pourfakhr
%A Mojtaba Mojtahedzade
%A Atabak Najafi
%A Reza Moharari
%A Kourosh Yarandi
%A Mohammad Khajavi
%J DARU Journal of Pharmaceutical Sciences
%D 2012
%I BioMed Central
%R 10.1186/2008-2231-20-36
%X 120 patients were randomly divided into two equal groups. In group A, bicarbonate was infused intra-operatively according to Base Excess (BE) measurements to achieve the normal values of BE (£¿5 to +5£¿mEq/L). In group B, infusion of bicarbonate was allowed only in case of severe metabolic acidosis (BE£¿¡Ü£¿£¿15£¿mEq/L or bicarbonate£¿¡Ü£¿10£¿mEq/L or PH£¿¡Ü£¿7.15). Minute ventilation was adjusted to keep PaCO2 within the normal range. Primary end-point was sampling of serum creatinine level in first, second, third and seventh post-operative days for statistical comparison between groups. Secondary objectives were comparison of cumulative urine volumes in the first 24£¿h of post-operative period and serum BUN levels which were obtained in first, second, third and seventh post-operative days.In group A, all of consecutive serum creatinine levels were significantly lower in comparison with group B. With regard to secondary outcomes, no significant difference between groups was observed.Intra-operative tight control of metabolic acidosis by infusion of Sodium Bicarbonate in renal transplant recipients may improve early post-operative renal function.Kidney transplantation is a cardinal method and the most cost-effective treatment modality used for the patients with chronic renal failure (CRF) [1].Experiments in animals show that premedication with Sodium Bicarbonate, before the development of ischemic damage in renal tubules, may have renoprotective effects [2,3]. It is obvious that transplanted kidney is under the risk of ischemic insult (warm and cold ischemic period).Furthermore, Infusion of sodium bicarbonate solution (8.4%), which is hyperosmolar, can shift intracellular water into interstitial and intravascular spaces leading to intravascular volume expansion and induces osmotic diuresis [4-6]. Meanwhile, the alkalization of the urine might increase the solubility of acidic materials accumulated in CRF patients and enhance their excretion through urine [7]. The main concern with
%K Acid¨Cbase disorder
%K Renal transplantation
%K Chronic renal failure
%K Sodium bicarbonate
%U http://www.darujps.com/content/20/1/36