%0 Journal Article
%T Positive effect of septimeb£¿ on mortality rate in severe sepsis: a novel non antibiotic strategy
%A Kaveh Eslami
%A Ata Mahmoodpoor
%A Arezoo Ahmadi
%A Mohammad Abdollahi
%A Koorosh Kamali
%A Sarah Mousavi
%A Atabak Najafi
%A Maryam Baeeri
%A Hadi Hamishehkar
%A Leila Kouti
%A Mohammad£¿Reza Javadi
%A Mojtaba Mojtahedzadeh
%J DARU Journal of Pharmaceutical Sciences
%D 2012
%I BioMed Central
%R 10.1186/2008-2231-20-40
%X In this multicenter, randomized, single-blind trial, we assigned patients with severe sepsis and Acute Physiology and Chronic Health Evaluation (APACHE II) score of more than 20 to receive standard treatment of severe sepsis (control group) or standard treatment plus Septimeb. This group was treated with Septimeb for 14 days then followed up for another14 days. APACHE score, Sequential Organ Failure Assessment (SOFA) and Simplified Acute Physiology Score (SAPS) were calculated daily. Blood samples were analyzed for interleukin 2 tumor necrosis factor-¦Á, total antioxidant power, platelet growth factor and matrix metalloproteinase 2.A total of 29 patients underwent randomization (13 in control group and 16 in Septimeb group). There was significant difference between the Septimeb and control group in the 14 days mortality rate (18.8% vs. 53.85 respectively, P=0.048). Compared to control group, Septimeb was significantly effective in improving SAPS (P= 0.029), SOFA (P=0.003) and APACHE II (P=0.008) scores. Inflammatory biomarkers didn¡¯t change significantly between the two groups (P>0.05).Septimeb reduces mortality rates among patients with severe sepsis and it could be added as a safe adjutant to standard treatment of sepsis.Sepsis is one of the most prevalent and fatal diseases in Intensive Care Units (ICU) resulted in 30-60% mortality [1,2]. Sepsis is a systemic inflammatory response to an infection leading to endothelial dysfunction, impairment of microcirculation, tissue hypoxia, apoptosis and finally multiple organ failure and death [3]. Nowadays the role of inflammatory cytokines, oxidative stress and immune system in the pathogenesis of sepsis is obvious. Continuous elevated levels of various cytokines in severe sepsis could result in uncontrolled inflammation [4-7]. Breaking of inflammatory cascade may lead to improving of survival [8]. A significant association exists between inflammatory cytokine levels in the first 72 hours of severe sepsis and severity of t
%K Severe sepsis
%K Immunomodulation
%K Septimeb
%K ICU
%U http://www.darujps.com/content/20/1/40