%0 Journal Article
%T Bronchoalveolar lavage cytological alveolar damage in patients with severe pneumonia
%A Bogdan Grigoriu
%A Fr¨¦d¨¦ric Jacobs
%A Fabienne Beuzen
%A Rony El Khoury
%A Olivier Axler
%A Francois G Brivet
%A Fr¨¦d¨¦rique Capron
%J Critical Care
%D 2005
%I BioMed Central
%R 10.1186/cc3912
%X We conducted a prospective study in mechanically ventilated patients with clinical suspicion of pneumonia. Patients were classified as having hospital-acquired pneumonia or not, in accordance with the quantitative microbiological cultures of respiratory tract specimens. A group of severe community-acquired pneumonias requiring mechanical ventilation during the same period was used for comparison. A specimen of BAL (20 ml) was taken for cytological analysis. A semiquantitative analysis of the dominant leukocyte population, the presence of erythrophages/siderophages and desquamated type II pneumocytes was performed.In patients with confirmed hospital-acquired pneumonia, we found that 13 out of 39 patients (33.3%) had erythrophages/siderophages in BAL, 18 (46.2%) had desquamated pneumocytes and 8 (20.5%) fulfilled both criteria. Among the patients with community-acquired pneumonia, 7 out of 15 (46.7%) had erythrophages/siderophages and 6 (40%) had desquamated pneumocytes on BAL cytology. Only four (26.7%) fulfilled both criteria. No patient without hospital-acquired pneumonia had erythrophages/siderophages and only 3 out of 18 (16.7%) had desquamated pneumocytes on BAL cytology.Cytological analysis of BAL from patients with pneumonia (either community-acquired or hospital-acquired) shows elements of cytological alveolar damage as hemorrhage and desquamated type II pneumocytes much more frequently than in BAL from patients without pneumonia. These elements had a high specificity for an infectious cause of pulmonary infiltrates but low specificity. These lesions could serve as an adjunct to diagnosis in patients suspected of having ventilator-associated pneumonia.Pneumonia is a common problem in critical care patients. Ventilator-associated pneumonia (VAP) complicates the course of as much as 27% of patients requiring mechanical ventilation [1,2]. Because mortality in patients with pneumonia is high and clinical studies have shown that an adequate antimicrobial treatment
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