%0 Journal Article
%T Increased incidence of glucose disorders during pregnancy is not explained by pre-pregnancy obesity in London, Canada
%A Margie H Davenport
%A M Karen Campbell
%A Michelle F Mottola
%J BMC Pregnancy and Childbirth
%D 2010
%I BioMed Central
%R 10.1186/1471-2393-10-85
%X Data arose from a perinatal database which contains maternal characteristics and perinatal outcome for all singleton infants born in London, Canada between January 1, 2000 and December 31, 2009. Univariable and multivariable odds ratios (OR) were estimated using logistic regression with IGT/GDM/T2 D being the outcome of interest.A total of 36,597 women were included in the analyses. Population incidence of IGT, GDM and T2 D rose from 0.7%, 2.9% and 0.5% in 2000 to 1.2%, 4.2% and 0.9% in 2009. The univariable OR for IGT, GDM and T2 D were 1.65, 1.52 and 2.06, respectively, over the ten year period. After controlling for maternal age, parity and pre-pregnancy BMI the OR did not decrease. Although there was a positive relationship between pre-pregnancy BMI and prevalence of IGT/GDM/T2 D, this did not explain the time trends in the latter. Diagnosis of IGT/GDM/T2 D increased the risk of having an Apgar score <7 at 5 minutes, which was partially explained by gestational hypertension, high placental ratio, gestational age and large for gestational age babies.We found a significant increase in the incidence of IGT/GDM/T2 D for the decade between 2000-2009 which was not explained by rising prevalence of maternal overweight/obesity.Maternal glucose disorders (MGD) during pregnancy include gestational diabetes mellitus (GDM), impaired glucose intolerance (IGT) and pre-pregnancy type 2 diabetes. GDM is defined as glucose intolerance with onset or first diagnosis during pregnancy [1,2]. This is a common disease affecting 3-4% of pregnancies in Canada [1]. Recent data from the United States and Australia have indicated that the prevalence of GDM is on the rise. However, the underlying cause is unknown [3-12]. Postulated mechanisms include the concomitant rise in obesity [12,13] and decrease in physical activity [14,15]. In 2000, 30% of American adults were obese (body mass index (BMI) ¡Ý30 kg/m2) representing a 23% increase over the previous decade [16]. In a study of nine US sta
%U http://www.biomedcentral.com/1471-2393/10/85