%0 Journal Article
%T The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study
%A Oliver P Stannus
%A Graeme Jones
%A Stephen J Quinn
%A Flavia M Cicuttini
%A Dawn Dore
%A Changhai Ding
%J Arthritis Research & Therapy
%D 2010
%I BioMed Central
%R 10.1186/ar3022
%X A cross-sectional sample of 193 randomly selected subjects (mean age, 63 years; range, 52 to 78 years; 48% female subjects) were studied. Hip ROA, including joint-space narrowing (JSN) and osteophytes, was determined by anteroposterior radiograph. Serum levels of leptin and interleukin (IL)-6 were measured with radioimmunoassay. Fat mass was measured with dual-energy x-ray absorptiometry (DXA). Body mass index (BMI) and waist-to-hip ratio (WHR) were calculated.In multivariable analysis, hip JSN was associated with serum levels of leptin in the whole sample (¦Â = 0.046 per ¦Ìg/L, P = 0.024 for superior; ¦Â = 0.068 per ¦Ìg/L, P = 0.004 for axial compartment) and IL-6 only in females (¦Â = 0.241 per pg/ml, P = 0.002 for superior; ¦Â = 0.239 per pg/ml, P = 0.001 for axial compartment). The positive associations between body-composition measures (BMI, WHR, percentage total fat mass, and percentage trunk fat mass) and hip JSN in women became nonsignificant after adjustment for leptin but not for IL-6. No significant associations were found between leptin, IL-6, and the presence or severity of osteophytes.This study suggests that metabolic and inflammatory mechanisms may play a role in the etiology of hip OA and that the associations between body composition and hip JSN are mediated by leptin, particularly in women.Osteoarthritis (OA) is a multifactorial disease of the joints characterized by gradual loss of articular cartilage. The main risk factors for OA are age [1], female sex [2], and obesity [1]. Studies of hip OA among predominantly white populations have estimated prevalence rates of ~5-7%, which are higher in women [3,4]. Body mass index (BMI) is strongly associated with prevalence [5] and incidence [6-8] of knee OA. Although inconsistent associations have been reported between BMI and hip OA [7,9-11], a systematic review has suggested that BMI is moderately associated with hip OA [12].Metabolic changes associated with obesity are a possible causative pathway for OA [13
%U http://arthritis-research.com/content/12/3/R95