%0 Journal Article
%T Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion
%A Nicola Dalbeth
%A Bregina Pool
%A Timothy Smith
%A Karen E Callon
%A Maria Lobo
%A William J Taylor
%A Peter B Jones
%A Jillian Cornish
%A Fiona M McQueen
%J Arthritis Research & Therapy
%D 2010
%I BioMed Central
%R 10.1186/ar3123
%X Patients with PsA (n = 38), with psoriasis (n = 10), and healthy controls (n = 12) were studied. Serum was obtained for testing of Dikkopf-1 (Dkk-1), macrophage-colony stimulating factor (M-CSF), osteoprotegerin (OPG), and receptor activator of nuclear factor-¦ĘB ligand (RANKL) with ELISA. Patients with PsA also had bone densitometry, plain radiographs of the hands and feet, and assessment of peripheral blood osteoclast precursors. Radiographs were scored for erosion, joint-space narrowing, osteolysis, and new bone formation.Compared with those with psoriasis and healthy controls, patients with PsA had higher circulating concentrations of Dkk-1 and M-CSF. In patients with PsA, M-CSF and RANKL, but not Dkk-1, concentrations positively correlated with radiographic erosion, joint-space narrowing, and osteolysis scores. Mediators of bone remodeling did not correlate with the number of joints with new bone formation or with total hip-bone mineral density. Peripheral blood CD14+/CD11b+ cells, and the number of osteoclast-like cells and resorptive pits after culture with RANKL and M-CSF also correlated with radiographic damage scores. Circulating M-CSF concentrations correlated with the percentage of peripheral blood CD14+/CD11b+ cells.Systemic expression of soluble factors that promote osteoclastogenesis is disordered in patients with PsA and may contribute to periarticular bone loss in this disease.Psoriatic arthritis (PsA) is an inflammatory arthritis with a number of characteristic clinical features [1]. PsA is typically associated with psoriasis and psoriatic nail disease and has both peripheral articular manifestations (including synovitis, dactylitis, and enthesitis) and axial skeletal involvement. A range of bone pathologies is observed in patients with PsA [2]. Bone loss can occur, either locally in the form of bone erosion and osteolysis affecting the peripheral joints, or systemically with loss of skeletal bone mineral density (BMD) [3]. Aberrant bone formation m
%U http://arthritis-research.com/content/12/4/R164