%0 Journal Article
%T Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis
%A Yanying Liu
%A Rong Mu
%A Shiyao Wang
%A Li Long
%A Xia Liu
%A Ru Li
%A Jian Sun
%A Jianping Guo
%A Xiaoping Zhang
%A Jing Guo
%A Ping Yu
%A Chunlei Li
%A Xiangyuan Liu
%A Zhenyu Huang
%A Dapeng Wang
%A Hu Li
%A Zhifeng Gu
%A Bing Liu
%A Zhanguo Li
%J Arthritis Research & Therapy
%D 2010
%I BioMed Central
%R 10.1186/ar3187
%X The effects of UC-MSCs on the responses of fibroblast-like synoviocytes (FLSs) and T cells in RA patients were explored. The possible molecular mechanism mediating this immunosuppressive effect of UC-MSCs was explored by addition of inhibitors to indoleamine 2,3-dioxygenase (IDO), Nitric oxide (NO), prostaglandin E2 (PGE2), transforming growth factor ¦Â1 (TGF-¦Â1) and interleukin 10 (IL-10). The therapeutic effects of systemic infusion of human UC-MSCs on collagen-induced arthritis (CIA) in a mouse model were explored.In vitro, UC-MSCs were capable of inhibiting proliferation of FLSs from RA patients, via IL-10, IDO and TGF-¦Â1. Furthermore, the invasive behavior and IL-6 secretion of FLSs were also significantly suppressed. On the other hand, UC-MSCs induced hyporesponsiveness of T cells mediated by PGE2, TGF-¦Â1 and NO and UC-MSCs could promote the expansion of CD4+ Foxp3+ regulatory T cells from RA patients. More importantly, systemic infusion of human UC-MSCs reduced the severity of CIA in a mouse model. Consistently, there were reduced levels of proinflammatory cytokines and chemokines (TNF-¦Á, IL-6 and monocyte chemoattractant protein-1) and increased levels of the anti-inflammatory/regulatory cytokine (IL-10) in sera of UC-MSCs treated mice. Moreover, such treatment shifted Th1/Th2 type responses and induced Tregs in CIA.In conclusion, human UC-MSCs suppressed the various inflammatory effects of FLSs and T cells of RA in vitro, and attenuated the development of CIA in vivo, strongly suggesting that UC-MSCs might be a therapeutic strategy in RA. In addition, the immunosuppressive activitiy of UC-MSCs could be prolonged by the participation of Tregs.Rheumatoid arthritis (RA) is a chronic and systemic disease that primarily attacks synovial joints, leading to articular destruction and functional disability. RA imparts a massive burden on health services worldwide. Efforts to discover new target therapies have achieved considerable success. For instance, TNF-¦Á inhibit
%U http://arthritis-research.com/content/12/6/R210